Regulation of interleukin-1-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of interleukin-1-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A8, UNC13D, and CAMP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of interleukin-1-mediated signaling pathway activity versus S100A8 in GBM (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	S100A8 →	+1.522	+0.139	<.001	<.001	3	7
GBM	UNC13D →	+0.438	+0.129	<.001	<.001	3	7
GBM	CAMP →	+1.779	+0.110	<.001	<.001	3	7
GBM	AMPD3 →	+0.644	+0.139	<.001	<.001	3	7
GBM	MNDA →	+1.157	+0.151	<.001	<.001	3	7
BRCA	PPP1R18_S368 →	+0.511	+0.062	.001	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000659 vs S100A8 — GBM

Explore this scatter interactively →