Regulation of interleukin-1-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of interleukin-1-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INPP4B, PTPN2P1, and SUPT16HP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of interleukin-1-mediated signaling pathway activity versus INPP4B in OV (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	INPP4B →	+0.636	+0.081	.005	.009	3	4
BRCA	PTPN2P1 →	+0.449	+0.912	.007	<.001	3	3
BRCA	SUPT16HP1 →	+0.399	+0.763	.009	.003	3	3
PDAC	ACADSB →	-0.389	-0.424	<.001	.004	3	3
PDAC	GNG5P2 →	+0.247	+0.505	.008	<.001	3	3
PDAC	KCNN3 →	-0.217	-0.341	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000659 vs INPP4B — OV

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