Regulation of interleukin-1-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of interleukin-1-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL27A, RPL39, and ZNF627, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of interleukin-1-mediated signaling pathway activity versus RPL27A in BLOOD_Myeloma (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RPL27A →	+0.823	+0.142	.006	<.001	3	6
CNS	RPL39 →	+0.785	+0.136	.003	<.001	3	6
BONE	ZNF627 →	+0.850	+0.129	<.001	<.001	3	6
SKIN	AKR7A2 →	-0.733	-0.139	<.001	.005	3	6
URINARY_TRACT	SPHK2 →	-0.656	-0.104	.006	<.001	3	5
CNS	CNIH1 →	+0.467	+0.107	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000659 vs RPL27A — BLOOD_Myeloma

Explore this scatter interactively →