Regulation of interleukin-1-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of interleukin-1-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GABBR1, SCD5, and IL1RAP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of interleukin-1-mediated signaling pathway activity versus GABBR1 in LUNG_NSCLC_LUAD (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GABBR1 →	-1.620	-0.354	<.001	<.001	3	5
LARGE_INTESTINE	SCD5 →	-2.848	-0.461	<.001	<.001	3	4
BLOOD_Lymphoma	IL1RAP →	+5.021	+1.087	<.001	.005	3	4
OVARY	NFE2 →	+0.625	+0.319	.006	.001	3	4
STOMACH	WDCP →	-0.779	-0.502	.004	.002	3	4
CNS	DENND2B →	+1.086	+0.450	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000659 vs GABBR1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →