Regulation of sodium ion transmembrane transporter activity

Across TCGA cell cohorts, RNA activity of the Regulation of sodium ion transmembrane transporter activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNK2, COX6B1, and ACTN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sodium ion transmembrane transporter activity activity versus WNK2 in LUNG_NSCLC_LUAD (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WNK2 →	-1.994	-0.339	.006	.001	3	4
LUNG_SCLC	COX6B1 →	+0.894	+0.170	.005	.007	3	4
LUNG_SCLC	ACTN4 →	+0.784	+0.217	.001	<.001	3	3
OESOPHAGUS	RAD54B →	-1.214	-0.227	.007	.007	3	3
LUNG_NSCLC_LUAD	PGM1 →	+0.945	+0.293	<.001	<.001	3	3
BREAST	IKBKB →	+0.871	+0.191	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000649 vs WNK2 — LUNG_NSCLC_LUAD

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