Positive regulation of stem cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of stem cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL5A1, CTHRC1, and FN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of stem cell proliferation activity versus COL5A1 in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	COL5A1 →	+0.907	+0.047	<.001	<.001	3	8
OV	CTHRC1 →	+1.054	+0.038	<.001	<.001	3	8
OV	FN1 →	+1.005	+0.039	<.001	<.001	3	8
LSCC	ANGPTL2 →	+0.783	+0.048	<.001	<.001	3	8
PDAC	CD109 →	+0.679	+0.054	<.001	<.001	3	8
OV	RAI14 →	+0.427	+0.060	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000648 vs COL5A1 — LSCC

Explore this scatter interactively →