Positive regulation of receptor catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM72B, NLGN4X, and PCDHGA11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor catabolic process activity versus FAM72B in COAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FAM72B →	+0.771	+0.466	.001	.007	3	3
BRCA	NLGN4X →	-0.745	-0.166	.001	.004	3	3
GBM	PCDHGA11 →	-0.599	-0.365	<.001	.005	3	3
UCEC	IRAK2 →	+0.854	+0.287	.001	.004	3	3
UCEC	RPS3AP53 →	-0.669	-0.224	.002	.004	3	3
BRCA	CPED1 →	-0.466	-0.161	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000646 vs FAM72B — COAD

Explore this scatter interactively →