Positive regulation of receptor catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of receptor catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB3, INPP5E, and LGALS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGB3 grouped by Positive regulation of receptor catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ITGB3 →	+2.555	+1.368	<.001	.004	3	6
URINARY_TRACT	INPP5E →	+0.785	+1.715	.006	<.001	3	5
BONE	LGALS1 →	+4.826	+1.383	.002	.004	3	5
BONE	APOBEC3F →	+1.178	+1.737	<.001	<.001	3	5
LIVER	NEXN →	+3.094	+1.929	<.001	<.001	3	5
LUNG_NSCLC_LUAD	NPC2 →	+0.917	+0.627	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGB3 by Positive regulation of receptor catabolic process activity — LIVER

Explore this box plot interactively →