Regulation of receptor catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of receptor catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS3A, TLN1, and RPS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor catabolic process activity versus RPS3A in OV (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPS3A →	-0.232	-0.046	.001	.002	3	5
GBM	TLN1 →	+0.310	+0.067	.002	.001	3	5
BRCA	RPS2 →	-0.168	-0.037	.001	.001	3	5
BRCA	CTSF →	+0.384	+0.043	.008	<.001	2	6
CCRCC	LMOD1_S85 →	+0.991	+0.044	<.001	.001	3	5
LSCC	MTMR2 →	+0.201	+0.042	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000644 vs RPS3A — OV

Explore this scatter interactively →