Regulation of receptor catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of receptor catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN1, DTX3L, and CRKL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN1 grouped by Regulation of receptor catabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PTPN1 →	-0.457	-1.583	<.001	<.001	3	8
KIDNEY	DTX3L →	-0.150	-1.105	<.001	<.001	3	6
LUNG_NSCLC_LUAD	CRKL →	-0.224	-1.065	<.001	<.001	3	6
BLOOD_Lymphoma	ITCH →	-0.555	-2.250	.006	<.001	3	6
LUNG_NSCLC_LUAD	FURIN →	-0.196	-0.642	<.001	.006	3	5
LUNG_SCLC	OXSR1 →	-0.161	-1.283	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN1 by Regulation of receptor catabolic process activity — STOMACH

Explore this box plot interactively →