Regulation of receptor catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of receptor catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENPP6, SMOC2, and PLAGL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ENPP6 grouped by Regulation of receptor catabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ENPP6 →	+0.226	+0.105	.003	.004	3	5
LARGE_INTESTINE	SMOC2 →	+0.176	+0.090	.008	.007	3	4
OESOPHAGUS	PLAGL2 →	+0.125	+0.137	.002	.001	3	4
BLOOD_Leukemia	NR5A1 →	-0.176	-0.113	.002	<.001	3	4
URINARY_TRACT	GBX1 →	+0.200	+0.264	.001	<.001	3	4
CNS	GLS →	-0.180	-0.086	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ENPP6 by Regulation of receptor catabolic process activity — SKIN

Explore this box plot interactively →