Regulation of receptor catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of receptor catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APOE, PTPN1, and UBE2K, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor catabolic process activity versus APOE in BLOOD_Lymphoma (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	APOE →	+1.747	+0.813	<.001	.002	3	15
PANCREAS	PTPN1 →	+1.598	+0.341	.001	.002	3	15
OVARY	UBE2K →	-1.889	-0.261	<.001	.003	3	13
STOMACH	RPL24 →	-1.046	-0.269	<.001	<.001	3	12
OVARY	PARK7 →	-1.464	-0.314	<.001	<.001	3	12
OVARY	NEDD8 →	-1.605	-0.302	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000644 vs APOE — BLOOD_Lymphoma

Explore this scatter interactively →