Positive regulation of early endosome to late endosome transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of early endosome to late endosome transport pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN23, NF2, and MAP4, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of early endosome to late endosome transport activity versus PTPN23 in URINARY_TRACT (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PTPN23 →	+1.045	+0.143	<.001	<.001	3	16
BONE	NF2 →	+1.457	+0.173	<.001	<.001	3	15
URINARY_TRACT	MAP4 →	+1.234	+0.134	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	CYB5R3 →	+1.251	+0.145	<.001	<.001	3	14
BREAST	CORO1C →	+1.556	+0.148	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	NCDN →	+0.978	+0.138	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000643 vs PTPN23 — URINARY_TRACT

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