Regulation of early endosome to late endosome transport

Across TCGA patient cohorts, RNA activity of the Regulation of early endosome to late endosome transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TUBB6, DNM1, and PDLIM3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of early endosome to late endosome transport activity versus TUBB6 in PDAC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TUBB6 →	+0.487	+0.036	<.001	<.001	3	7
BRCA	DNM1 →	+0.343	+0.023	<.001	.001	3	7
BRCA	PDLIM3 →	+0.429	+0.026	<.001	<.001	3	7
LSCC	MAP1A →	+0.372	+0.029	.001	.009	2	8
COAD	RIPOR1 →	+0.251	+0.043	<.001	<.001	3	6
LSCC	UCHL1 →	+0.900	+0.045	.005	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000641 vs TUBB6 — PDAC

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