Regulation of early endosome to late endosome transport

Across TCGA patient cohorts, RNA activity of the Regulation of early endosome to late endosome transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FHL1, FBLN5, and EFEMP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of early endosome to late endosome transport activity versus FHL1 in HNSC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FHL1 →	+1.521	+0.143	<.001	<.001	3	8
LUAD	FBLN5 →	+0.914	+0.147	<.001	.003	3	8
UCEC	EFEMP1 →	+1.138	+0.152	<.001	.001	3	7
UCEC	COLEC12 →	+0.891	+0.185	.001	<.001	3	7
UCEC	DDR2 →	+0.906	+0.157	<.001	<.001	3	7
COAD	MSRB3 →	+0.733	+0.097	.009	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000641 vs FHL1 — HNSC

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