Regulation of early endosome to late endosome transport

Across TCGA cell cohorts, RNA activity of the Regulation of early endosome to late endosome transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHST12, RALY, and BTBD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHST12 grouped by Regulation of early endosome to late endosome transport-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CHST12 →	-1.073	-1.419	.001	.001	3	4
KIDNEY	RALY →	+0.560	+0.485	.003	.007	3	4
KIDNEY	BTBD3 →	+0.800	+0.674	.004	.009	3	4
BREAST	ESS2 →	+0.534	+0.607	.005	.005	3	3
BLOOD_Myeloma	JCAD →	-0.135	-1.295	.004	.005	3	3
SKIN	C9orf72 →	+0.779	+0.765	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHST12 by Regulation of early endosome to late endosome transport activity — BLOOD_Myeloma

Explore this box plot interactively →