Regulation of SREBP signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of SREBP signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC113, RPS27AP11, and RN7SL192P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of SREBP signaling pathway activity versus CCDC113 in LSCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCDC113 →	+0.701	+0.585	.001	<.001	3	3
LSCC	RPS27AP11 →	-0.460	-0.362	.004	.005	3	3
LSCC	RN7SL192P →	-0.432	-0.446	<.001	<.001	3	3
LUAD	SNU13 →	+0.238	+0.277	.003	.008	3	3
GBM	MAP2K4P1 →	-0.318	-0.541	.005	<.001	3	3
BRCA	LIG1 →	-0.470	-0.515	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000638 vs CCDC113 — LSCC

Explore this scatter interactively →