Regulation of pre-miRNA processing

Across TCGA patient cohorts, RNA activity of the Regulation of pre-miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, CDC25C, and CIT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pre-miRNA processing activity versus TTK in LUAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TTK →	+1.127	+0.616	<.001	.005	3	6
LUAD	CDC25C →	+0.895	+0.625	<.001	.005	3	6
BRCA	CIT →	+0.563	+0.476	<.001	.001	3	5
LSCC	KIF11 →	+0.768	+0.554	.001	.001	3	5
BRCA	SPC25 →	+0.622	+0.353	<.001	<.001	3	5
BRCA	RFC3 →	+0.549	+0.370	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000631 vs TTK — LUAD

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