Regulation of pre-miRNA processing

Across TCGA cell cohorts, RNA activity of the Regulation of pre-miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA2B, FRY, and SLC39A14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pre-miRNA processing activity versus ITGA2B in OVARY (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ITGA2B →	+1.440	+2.253	.003	.006	3	3
BLOOD_Leukemia	FRY →	-3.546	-0.392	<.001	.002	3	2
OVARY	SLC39A14 →	+1.784	+2.253	.003	.006	3	2
OVARY	TRMT1L →	+1.259	+2.253	.002	.006	3	2
OVARY	ATIC →	+1.344	+2.253	.001	.006	3	2
OVARY	RDH14 →	+0.585	+2.253	.005	.006	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000631 vs ITGA2B — OVARY

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