Positive regulation of miRNA metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of miRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STARD10, ZMAT3, and B9D2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STARD10 grouped by Positive regulation of miRNA metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	STARD10 →	+1.706	+0.204	.002	.002	3	5
LARGE_INTESTINE	ZMAT3 →	-1.029	-0.212	.002	.002	3	4
LUNG_NSCLC_LUAD	B9D2 →	-0.652	-0.168	.002	.007	3	4
LUNG_NSCLC_LUAD	RILPL2 →	-0.774	-0.197	.001	<.001	3	4
LUNG_NSCLC_LUAD	CDH1 →	+1.804	+0.150	.007	.001	3	4
LARGE_INTESTINE	TIFA →	-1.332	-0.222	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STARD10 by Positive regulation of miRNA metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →