Positive regulation of miRNA metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of miRNA metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB6C, COX6A1, and CDK18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB6C grouped by Positive regulation of miRNA metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RAB6C →	+0.096	+0.862	.001	.003	3	4
SOFT_TISSUE	COX6A1 →	-0.339	-1.434	.001	<.001	3	3
SOFT_TISSUE	CDK18 →	-0.220	-1.553	.008	<.001	3	3
SOFT_TISSUE	CDC20 →	-0.343	-1.540	.005	<.001	3	3
SKIN	AQP11 →	-0.149	-1.118	.001	<.001	3	3
SOFT_TISSUE	TLN2 →	-0.270	-1.531	.007	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB6C by Positive regulation of miRNA metabolic process activity — BREAST

Explore this box plot interactively →