Regulation of miRNA metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of miRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS2, SRSF2, and SNORA22C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of miRNA metabolic process activity versus GINS2 in LUAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GINS2 →	+0.711	+0.291	<.001	.004	3	5
LUAD	SRSF2 →	+0.305	+0.312	<.001	.002	3	5
GBM	SNORA22C →	+0.809	+0.734	<.001	.002	3	5
HNSC	USP34 →	+0.595	+0.541	.006	.004	3	4
HNSC	THUMPD2 →	+0.475	+0.426	.002	.003	3	4
HNSC	CDK13 →	+0.429	+0.526	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000628 vs GINS2 — LUAD

Explore this scatter interactively →