Regulation of miRNA metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of miRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GM2A, BIN3, and ZMAT3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GM2A grouped by Regulation of miRNA metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GM2A →	+1.336	+0.227	.003	.001	3	4
STOMACH	BIN3 →	-0.787	-0.244	.007	.005	3	4
STOMACH	ZMAT3 →	-1.398	-0.212	<.001	.003	3	4
LUNG_NSCLC_LUSC	CENPP →	+1.280	+0.211	.003	.007	3	4
LUNG_NSCLC_LUSC	EDEM2 →	+1.575	+0.324	.001	<.001	3	4
SOFT_TISSUE	GLB1L →	-0.880	-0.257	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GM2A by Regulation of miRNA metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →