Regulation of miRNA metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of miRNA metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAA10, PPIH, and XBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NAA10 grouped by Regulation of miRNA metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NAA10 →	-0.268	-1.050	.007	.002	3	4
BREAST	PPIH →	+0.188	+1.343	<.001	<.001	3	4
BREAST	XBP1 →	+0.190	+0.795	.004	.004	2	4
BREAST	PRMT7 →	+0.190	+1.120	.001	<.001	3	3
LUNG_NSCLC_LUAD	PCDHB16 →	+0.192	+0.810	.001	.006	3	3
BLOOD_Lymphoma	CASP2 →	-0.410	-1.618	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NAA10 by Regulation of miRNA metabolic process activity — BREAST

Explore this box plot interactively →