Regulation of miRNA metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of miRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACNA1D, LIN54, and MT2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of miRNA metabolic process activity versus CACNA1D in URINARY_TRACT (Pearson r = -0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CACNA1D →	-1.712	-1.750	.001	<.001	3	5
LUNG_SCLC	LIN54 →	-0.789	-1.179	<.001	<.001	3	4
URINARY_TRACT	MT2A →	+4.265	+1.544	.003	<.001	3	4
URINARY_TRACT	LMTK2 →	-0.850	-1.292	<.001	.002	3	4
URINARY_TRACT	RTKN2 →	-1.887	-1.575	.001	<.001	3	4
PANCREAS	PTDSS2 →	+0.983	+0.808	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000628 vs CACNA1D — URINARY_TRACT

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