Regulation of miRNA catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of miRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC42P2, NECAB3, and HTR3A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of miRNA catabolic process activity versus CDC42P2 in OV (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDC42P2 →	+0.412	+0.557	<.001	.001	3	3
CCRCC	NECAB3 →	+0.351	+0.237	.002	.008	3	3
CCRCC	HTR3A →	+0.192	+0.187	.008	.008	3	3
CCRCC	ABCC2 →	+1.129	+0.367	.001	.002	3	3
HNSC	CYP2D6 →	-0.377	-0.346	.002	.001	3	3
BRCA	GAPDHP54 →	-0.091	-0.663	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000625 vs CDC42P2 — OV

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