Regulation of miRNA catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of miRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFUS, C16orf71, and MADCAM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GFUS grouped by Regulation of miRNA catabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GFUS →	+1.033	+0.247	.006	.004	2	4
LUNG_SCLC	C16orf71 →	-0.659	-0.433	.001	<.001	3	3
LUNG_SCLC	MADCAM1 →	-0.472	-0.288	.008	.008	3	3
LUNG_NSCLC_LUSC	RAI14 →	+1.509	+0.275	.002	.002	3	3
UPPER_AERODIGESTIVE_TRACT	GALNT6 →	+1.768	+0.257	.002	.006	3	3
STOMACH	NUDT21 →	-0.509	-0.197	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GFUS by Regulation of miRNA catabolic process activity — OESOPHAGUS

Explore this box plot interactively →