Regulation of miRNA catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of miRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIP2A, HDDC3, and SYNCRIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of miRNA catabolic process activity versus CIP2A in LIVER (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CIP2A →	+1.236	+0.271	<.001	<.001	3	5
URINARY_TRACT	HDDC3 →	-0.884	-0.265	<.001	<.001	3	5
LIVER	SYNCRIP →	+0.969	+0.271	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RNF224 →	+1.065	+0.375	.008	.001	3	4
BREAST	QKI →	+1.805	+0.356	.001	<.001	3	4
LIVER	RBSN →	+1.123	+0.271	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000625 vs CIP2A — LIVER

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