"Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSTF3, DHX9, and UBA2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" activity versus CSTF3 in GBM (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CSTF3 →	+0.314	+0.057	<.001	.001	3	6
GBM	DHX9 →	+0.205	+0.056	.001	.001	3	6
COAD	UBA2 →	+0.267	+0.044	.003	<.001	2	7
HNSC	CPSF1 →	+0.126	+0.063	<.001	<.001	3	6
UCEC	PRKDC →	+0.238	+0.053	.008	.001	3	6
HNSC	PRMT1 →	+0.212	+0.057	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000623 vs CSTF3 — GBM

Explore this scatter interactively →