"Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS41, TPRA1, and UNC79, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VPS41 grouped by "Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	VPS41 →	+0.950	+0.208	.004	.005	3	4
OESOPHAGUS	TPRA1 →	+0.753	+0.250	.001	.001	3	4
LUNG_SCLC	UNC79 →	-2.675	-0.257	.001	.008	3	4
LUNG_SCLC	PAN2 →	-1.278	-0.273	.004	.004	3	4
LUNG_SCLC	MYC →	+2.995	+0.192	.006	.008	3	4
PANCREAS	AUH →	-0.747	-0.307	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VPS41 by "Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" activity — LIVER

Explore this box plot interactively →