"Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRIP1, CHAF1A, and UHRF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" activity versus BRIP1 in LUNG_SCLC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BRIP1 →	+1.082	+0.203	<.001	.001	3	7
PANCREAS	CHAF1A →	+1.114	+0.274	.002	<.001	3	6
PANCREAS	UHRF1 →	+1.742	+0.325	.003	.002	3	6
OESOPHAGUS	UPF1 →	+0.987	+0.196	.001	.006	2	7
BLOOD_Myeloma	TTF2 →	+1.583	+0.153	<.001	<.001	3	5
PANCREAS	GTPBP3 →	+0.947	+0.337	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000623 vs BRIP1 — LUNG_SCLC

Explore this scatter interactively →