Positive regulation of thyroid hormone generation

Across TCGA patient cohorts, RNA activity of the Positive regulation of thyroid hormone generation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GLOD4, ACTR2, and PALM3_S439, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of thyroid hormone generation activity versus GLOD4 in OV (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GLOD4 →	+0.611	+0.074	<.001	.002	3	4
OV	ACTR2 →	-0.141	-0.062	.002	.002	3	4
LSCC	PALM3_S439 →	+1.220	+0.096	<.001	.001	3	4
BRCA	HAGH →	+0.305	+0.053	.001	.009	3	4
CCRCC	TBC1D2B_S155 →	-0.198	-0.060	.001	.001	3	4
CCRCC	AFAP1_S283 →	-0.291	-0.062	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000611 vs GLOD4 — OV

Explore this scatter interactively →