Positive regulation of thyroid hormone generation

Across TCGA cell cohorts, RNA activity of the Positive regulation of thyroid hormone generation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAX8, GATA3, and NEURL3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of thyroid hormone generation activity versus PAX8 in SOFT_TISSUE (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PAX8 →	+2.943	+1.593	<.001	<.001	3	13
BREAST	GATA3 →	+3.160	+1.069	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	NEURL3 →	+1.278	+0.745	<.001	.002	3	7
OESOPHAGUS	TMBIM1 →	+1.281	+1.114	<.001	<.001	3	7
BLOOD_Lymphoma	CAPN2 →	+2.474	+0.968	<.001	<.001	3	6
OESOPHAGUS	CBX2 →	-1.356	-1.121	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000611 vs PAX8 — SOFT_TISSUE

Explore this scatter interactively →