Regulation of platelet-derived growth factor receptor-alpha signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of platelet-derived growth factor receptor-alpha signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXL16, INIP, and SNORD114-3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet-derived growth factor receptor-alpha signaling pathway activity versus FBXL16 in BRCA (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FBXL16 →	-1.275	-0.640	<.001	<.001	3	3
BRCA	INIP →	-0.468	-0.879	<.001	<.001	3	3
HNSC	SNORD114-3 →	+1.046	+0.533	.002	.002	3	3
GBM	ALAD →	-0.444	-0.241	<.001	.001	3	3
GBM	LGALS7B →	+0.280	+0.249	.002	.001	3	3
GBM	CT62 →	-0.118	-0.279	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000583 vs FBXL16 — BRCA

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