Regulation of platelet-derived growth factor receptor-alpha signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of platelet-derived growth factor receptor-alpha signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PODXL2, HASPIN, and PGAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet-derived growth factor receptor-alpha signaling pathway activity versus PODXL2 in SOFT_TISSUE (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PODXL2 →	+2.880	+1.505	.006	.002	3	4
OVARY	HASPIN →	+1.306	+1.531	<.001	<.001	3	4
SOFT_TISSUE	PGAP1 →	+1.568	+1.485	.001	.002	3	4
LUNG_SCLC	ASPRV1 →	+0.578	+0.882	<.001	.001	3	4
LIVER	DRC3 →	+1.150	+1.883	.005	<.001	3	4
CNS	OASL →	-1.652	-1.001	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000583 vs PODXL2 — SOFT_TISSUE

Explore this scatter interactively →