Positive regulation of DNA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDHAL6A, NCR3LG1, and MACROD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA biosynthetic process activity versus LDHAL6A in COAD (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LDHAL6A →	+0.175	+0.130	.004	.002	3	3
COAD	NCR3LG1 →	+0.714	+0.139	<.001	.002	3	3
OV	MACROD1 →	+0.669	+0.116	.001	<.001	3	3
LSCC	THAP12 →	+0.636	+0.124	.003	.005	3	3
OV	CHRNA1 →	-0.665	-0.099	.005	.004	3	3
OV	WNT8B →	+0.278	+0.104	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000573 vs LDHAL6A — COAD

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