"Positive regulation of CD4-positive, alpha-beta T cell proliferation"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell proliferation" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TACC2, PRKCQ_T538, and TBC1D2B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD4-positive, alpha-beta T cell proliferation" activity versus TACC2 in LSCC (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TACC2 →	-0.425	-0.078	.001	.002	3	8
UCEC	PRKCQ_T538 →	+1.107	+0.101	<.001	<.001	3	8
GBM	TBC1D2B →	+0.300	+0.091	<.001	<.001	3	8
GBM	HLA-DPB1 →	+0.707	+0.066	<.001	<.001	3	8
LSCC	PSMB10 →	+0.540	+0.136	<.001	<.001	3	8
BRCA	RCSD1_S298 →	+0.829	+0.080	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000563 vs TACC2 — LSCC

Explore this scatter interactively →