"Positive regulation of CD4-positive, alpha-beta T cell proliferation"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell proliferation" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL15RA, APOBEC3H, and GIMAP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD4-positive, alpha-beta T cell proliferation" activity versus IL15RA in BRCA (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL15RA →	+0.787	+0.595	<.001	<.001	3	8
LUAD	APOBEC3H →	+0.594	+0.630	.003	.004	3	7
BRCA	GIMAP2 →	+0.854	+0.595	.001	.003	3	7
HNSC	SAMHD1 →	+0.757	+0.800	<.001	<.001	3	6
BRCA	CRTAM →	+0.668	+0.672	<.001	<.001	3	6
LSCC	LPXN →	+0.547	+0.669	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000563 vs IL15RA — BRCA

Explore this scatter interactively →