"Positive regulation of CD4-positive, alpha-beta T cell proliferation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell proliferation" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5MC3, EIF4G2, and PIK3C2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP5MC3 grouped by "Positive regulation of CD4-positive, alpha-beta T cell proliferation"-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ATP5MC3 →	+0.765	+1.545	.001	.002	3	4
OVARY	EIF4G2 →	+0.673	+1.067	<.001	<.001	3	3
OVARY	PIK3C2A →	+0.963	+1.009	.001	.008	3	3
OVARY	ARFIP2 →	+0.721	+1.005	<.001	.001	3	3
OVARY	HSPG2 →	-1.399	-1.018	.005	.005	3	3
STOMACH	DDOST →	-0.629	-1.052	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP5MC3 by "Positive regulation of CD4-positive, alpha-beta T cell proliferation" activity — STOMACH

Explore this box plot interactively →