"Positive regulation of CD4-positive, alpha-beta T cell proliferation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell proliferation" pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMD4A, VCPKMT, and RAP2C, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD4-positive, alpha-beta T cell proliferation" activity versus SAMD4A in LARGE_INTESTINE (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SAMD4A →	-1.553	-0.779	<.001	.002	3	3
BLOOD_Leukemia	VCPKMT →	-0.748	-1.088	.001	.003	3	3
BLOOD_Leukemia	RAP2C →	-0.830	-1.216	.002	.003	3	3
BLOOD_Leukemia	PLPP7 →	+1.572	+0.932	.002	.001	3	3
BREAST	SNX16 →	-0.800	-1.930	.006	<.001	3	3
BREAST	MDGA1 →	-2.073	-1.787	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000563 vs SAMD4A — LARGE_INTESTINE

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