"Negative regulation of CD4-positive, alpha-beta T cell proliferation"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell proliferation" pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD274, P2RY10, and PLEK, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD4-positive, alpha-beta T cell proliferation" activity versus CD274 in MESO (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	CD274 →	+2.033	+0.055	<.001	<.001	3	29
DLBC	P2RY10 →	+1.806	+0.084	<.001	<.001	3	29
UVM	PLEK →	+2.439	+0.052	<.001	<.001	3	28
DLBC	CD80 →	+1.395	+0.112	<.001	.004	3	28
DLBC	LILRB2 →	+1.605	+0.084	<.001	<.001	3	28
SKCM	IL2RA →	+1.446	+0.058	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000562 vs CD274 — MESO

Explore this scatter interactively →