"Negative regulation of CD4-positive, alpha-beta T cell proliferation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell proliferation" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TWSG1, VSIR, and OPTN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD4-positive, alpha-beta T cell proliferation" activity versus TWSG1 in LUNG_SCLC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TWSG1 →	+0.976	+0.658	.004	.007	3	8
BLOOD_Myeloma	VSIR →	+1.938	+1.042	.002	.001	3	7
BREAST	OPTN →	+1.663	+0.705	.001	.009	3	7
OESOPHAGUS	CBX2 →	-1.514	-0.160	<.001	<.001	3	6
BREAST	ZNF444 →	-0.813	-0.740	.001	.001	3	6
BLOOD_Lymphoma	LGALS9 →	+2.251	+0.556	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000562 vs TWSG1 — LUNG_SCLC

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