"Negative regulation of CD4-positive, alpha-beta T cell proliferation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell proliferation" pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN14, NRXN2, and GAL3ST3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLDN14 grouped by "Negative regulation of CD4-positive, alpha-beta T cell proliferation"-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CLDN14 →	+0.565	+1.723	.005	.008	3	2
OESOPHAGUS	NRXN2 →	+0.265	+2.387	.001	.005	3	2
PANCREAS	GAL3ST3 →	-0.150	-0.558	.007	.003	3	1
PANCREAS	ZNF329 →	-0.126	-0.558	.003	.003	3	1
PANCREAS	PCDHB11 →	-0.302	-0.465	.003	.005	3	1
PANCREAS	GFPT1 →	-0.300	-0.558	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLDN14 by "Negative regulation of CD4-positive, alpha-beta T cell proliferation" activity — BLOOD_Leukemia

Explore this box plot interactively →