"Negative regulation of CD4-positive, alpha-beta T cell proliferation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell proliferation" pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX16, WNT9A, and BTNL9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD4-positive, alpha-beta T cell proliferation" activity versus SNX16 in PANCREAS (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SNX16 →	+0.902	+0.443	.006	<.001	3	2
PANCREAS	WNT9A →	+1.744	+0.542	.003	<.001	3	2
PANCREAS	BTNL9 →	-2.257	-0.522	.006	<.001	3	2
PANCREAS	CLIC3 →	+2.195	+0.440	.005	.007	2	3
BLOOD_Leukemia	MRTO4 →	+0.874	+0.834	.002	.007	3	2
BLOOD_Lymphoma	UTP11 →	+0.955	+2.183	.004	.006	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000562 vs SNX16 — PANCREAS

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