Positive regulation of T-helper 2 cell cytokine production

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 2 cell cytokine production pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CORO1A, AMPD3, and SKAP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 2 cell cytokine production activity versus CORO1A in UCEC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CORO1A →	+0.517	+0.066	<.001	<.001	3	8
OV	AMPD3 →	+0.456	+0.063	.001	<.001	3	8
HNSC	SKAP2 →	+0.441	+0.055	<.001	.003	3	7
UCEC	STX11 →	+0.849	+0.079	<.001	<.001	3	7
LSCC	UNC13D →	+0.489	+0.080	<.001	<.001	3	7
COAD	DMXL2 →	+0.435	+0.040	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000553 vs CORO1A — UCEC

Explore this scatter interactively →