Positive regulation of T-helper 2 cell cytokine production

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 2 cell cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCF15, ZNF281, and LINC00618, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 2 cell cytokine production activity versus TCF15 in UCEC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TCF15 →	-0.576	-0.732	.006	<.001	3	3
COAD	ZNF281 →	-0.487	-0.578	<.001	<.001	3	3
GBM	LINC00618 →	-0.385	-0.613	.008	<.001	3	3
LUAD	HELLPAR →	-0.301	-0.313	.003	.007	3	3
UCEC	FLT1 →	-0.640	-0.811	<.001	<.001	3	2
UCEC	NT5DC3 →	-0.536	-0.707	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000553 vs TCF15 — UCEC

Explore this scatter interactively →