Positive regulation of T-helper 2 cell cytokine production

Across TCGA cell cohorts, RNA activity of the Positive regulation of T-helper 2 cell cytokine production pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CES5A, POLR2E, and THOC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CES5A grouped by Positive regulation of T-helper 2 cell cytokine production-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CES5A →	-0.204	-0.156	<.001	.007	3	6
BONE	POLR2E →	-0.447	-0.326	.009	<.001	3	4
STOMACH	THOC3 →	+0.250	+0.301	.002	<.001	3	4
KIDNEY	RER1 →	+0.240	+0.311	.006	.001	3	4
SOFT_TISSUE	MAF →	+0.264	+0.256	.008	.002	3	4
LUNG_SCLC	CRKL →	+0.228	+0.194	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CES5A by Positive regulation of T-helper 2 cell cytokine production activity — LUNG_SCLC

Explore this box plot interactively →