Regulation of entry of bacterium into host cell

Across TCGA patient cohorts, RNA activity of the Regulation of entry of bacterium into host cell pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT6A, CRCT1, and S100A8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of entry of bacterium into host cell activity versus KRT6A in PDAC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KRT6A →	+2.874	+0.305	<.001	<.001	3	6
LSCC	CRCT1 →	+1.337	+0.250	.006	<.001	3	5
HNSC	S100A8 →	+1.813	+0.218	.002	<.001	3	5
LSCC	IVL →	+2.169	+0.258	<.001	<.001	3	4
LSCC	SPRR1A →	+2.180	+0.156	<.001	<.001	3	4
LSCC	KRT6B →	+1.888	+0.178	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000535 vs KRT6A — PDAC

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