Regulation of entry of bacterium into host cell

Across TCGA cell cohorts, RNA activity of the Regulation of entry of bacterium into host cell pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2J, KCNJ12, and TEAD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR2J grouped by Regulation of entry of bacterium into host cell-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	POLR2J →	-0.318	-0.173	<.001	<.001	3	5
BLOOD_Leukemia	KCNJ12 →	-0.176	-0.132	.001	<.001	3	5
BREAST	TEAD3 →	+0.157	+0.171	.004	.001	3	5
BREAST	CRK →	+0.144	+0.191	<.001	<.001	3	5
SKIN	NCR2 →	-0.167	-0.112	<.001	.005	3	4
LUNG_SCLC	STX4 →	-0.252	-0.220	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR2J by Regulation of entry of bacterium into host cell activity — CNS

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