Regulation of entry of bacterium into host cell

Across TCGA cell cohorts, RNA activity of the Regulation of entry of bacterium into host cell pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFAP1L2, CAV2, and CAV1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of entry of bacterium into host cell activity versus AFAP1L2 in LIVER (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AFAP1L2 →	+2.992	+0.728	<.001	.007	3	6
BREAST	CAV2 →	+4.648	+1.237	<.001	<.001	3	6
BREAST	CAV1 →	+5.103	+1.056	<.001	.009	3	6
BREAST	IRF1 →	+1.645	+1.067	<.001	<.001	3	6
LUNG_SCLC	SMAD3 →	+2.020	+1.311	.002	.001	3	6
OESOPHAGUS	S100A2 →	+3.725	+0.948	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000535 vs AFAP1L2 — LIVER

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